We studied a man made peptide agonist that’s selective for MC4R highly. The medication, MC4R agonist LY2112688, had an elevated affinity for MC4R over MC1R of more than a factor of 30 and over MC3R of more than one factor of 100. Administration of the MC4R agonist to obese or overweight volunteers produced the traditional symptoms of yawning, stretching, and penile erection connected with activation of central MC4R and a marked short-term upsurge in blood circulation pressure that was sustained for the 7 days of the drug’s administration. The average upsurge in systolic and diastolic blood pressure in these research was quantitatively like the difference in blood circulation pressure between MC4R-deficient topics and control subjects.The most important lesson is that incentives work. This pressure exists almost but is particularly intense in China everywhere. It is consequently no surprise that the the majority of inventive ways to game the peer-review system to get manuscripts published have come from China. The companies mentioned above that provide fake peer testimonials all result from China and countries in Southeast Asia, & most of the authors involved in these cases come from the same areas. But it will be a mistake to check out this as a Chinese or Asian problem. The nagging problem may be the perverse incentive systems in scientific publishing.