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‘The previously demonstrated capability of AC-100 to market regeneration of underlying broken bone makes the use of AC-100 a distinctive approach for fix and regeneration of hard tissue in OA, RA, and traumatic injury.’.. Acologix presents preclinical research results of AC-100 on cartilage regeneration at ORS annual meeting Acologix, Inc., a kept biopharmaceutical company privately, today announced the results of its latest preclinical research demonstrating that AC-100, its therapeutic product applicant produced from an endogenous human protein, promotes cartilage regeneration in a large animal model. David M. Rosen on March 6, 2010 at the 56th annual conference of the ORS in New Orleans, LA. The effects of AC-100 on cartilage regeneration were evaluated in goats with standardized defects in knee cartilage.