PLA2R1 encodes a proteins that probably is present in both a transmembrane form and a soluble form. The transmembrane receptor might upsurge in the clearance of phospholipase A2, inhibiting its action thereby. PLA2R1 exists in normal podocytes and in immune deposits in patients with idiopathic membranous nephropathy. Sequence variations in PLA2R1 that are related to idiopathic membranous nephropathy could control the pattern of antigen-peptide digesting through conformational modification.34 For example, it is conceivable that the amino acid substitution M292V encoded by SNP rs3749117 may lead to a conformational transformation in PLA2R1, leading to its functioning as an antigen; there is precedence for such a situation.35 Furthermore, this or other sulfhydryl groups on the extracytoplasmic domains within this molecule could be modified due to environmental, accidental, or therapy-related contact with heavy metals , a known reason behind secondary membranous nephropathy.36-39 We speculate that sequence variants within HLA-DQA1 alleles that are unique to idiopathic membranous nephropathy result in the presentation of such peptides to immunocompetent cells, leading to autoantibody formation.XIENCE V met its main endpoint in the SPIRIT III clinical trial with a statistically significant 50 % reduction in in-segment late reduction at eight a few months compared to TAXUS. The XIENCE V stent can be on both over-the-cable and quick exchange delivery systems. Rapid exchange may be the most broadly used kind of delivery system since it provides physicians extra flexibility to are single operators during stent methods.