In one study, constant glucose monitoring data gathered from several women with type 2 diabetes led to the conclusion that greater glycemic variability may be associated with negative moods and lower quality of life, as described in the article Does Glycemic Variability Influence Mood and Standard of living? by Sue Penckofer, PhD, RN, Loyola University Chicago, Maywood, IL, and colleagues from University of Illinois at Chicago, Saint Mary’s College , mfmillstat, Ltd. , and Integrated Medical Advancement .. A better understanding of link between glycemic variability and psychological disorders needed When blood sugar in diabetes are controlled poorly, patients generally have more problems such as depression and other mood disturbances, including anxiety and anger, and a lesser overall standard of living.Findings had been replicated in a cohort of 1454 Northern European individuals and 1666 controls. The findings hyperlink five SNPs to ANCA-associated vasculitis, three of which were in the region of the major histocompatibility complex . Each one of these SNPs were associated to some degree with granulomatosis with polyangiitis, but none were associated with microscopic polyangiitis. Further evaluation showed that both the HLA and SERPINA1 associations with granulomatosis with polyangiitis were seen in patients with proteinase 3 autoreactivity, however, not in people that have myeloperoxidase autoreactivity. Related StoriesResearchers discover better genetic diversity among tumor cells than anticipatedFlorida Institute finalizes financing agreement with Genetic NetworksBerkeley Lab scientists identify genetic factors that impact neurological disorders and body weightThe researchers say this finding suggests that genetic background may donate to the medical classifications of granulomatosis with polyangiitis and microscopic polyangiitis.