All the patients provided written educated consent. Study Design In this multicenter, randomized, open-label trial, all of the patients received a fixed-dosage combination tablet containing 90 mg of ledipasvir and 400 mg of sofosbuvir, administered orally once daily. Randomization was stratified regarding to HCV genotype . Study Assessments The principal efficacy end point was an HCV RNA level of less than 25 IU per milliliter at 12 weeks following the end of therapy . This end point was assessed in all the sufferers who underwent randomization and received at least one dose of a report drug. In the principal efficacy analysis, the price of sustained virologic response in each one of the three treatment groups was compared with a calculated historic response rate of 60 percent.Skelton and his study team reviewed medical literature published between 1990 and 2011 to recognize the use of prominent family members theories in pediatric weight problems research. Of the 76 manuscripts found, 13 were selected for the scholarly research. Wake Forest Baptist experts found limited use of family theories in the analysis of pediatric obesity, in weight management treatments particularly. Family behavioral theories can provide valuable insight in to the complexities of households, and increased usage of these theories in both study and practice can help in the development of more effective treatments for childhood weight problems, the study found.