– The epothilones and taxanes are the anti-cancer drug Taxol already in use, the researchers have now investigated two drug candidates families. Both drugs work division of cancer cells division of cancer cells by binding to the same site on a protein called tubulin, Tubulin cell division. Tubulin is the major component of microtubules, the hollow cylinder, which serve as a skeletal system for cells and scaffold for chromosomes in dividing cell. When epothilones or taxanes tubulin tubulin, the protein loses its flexibility and the microtubules disassemble no longer to stop cell division.
The discovery potentially opens the door for the creation of more effective cancer treatments. The detection and mapping the structure of this model system will around the world around the world in creating new connections that lead hopefully to new cancer drugs, says researcher Jim Snyder, a chemist and director of Emory University biostructural.
The results, in the sixth August issue of the journal Science reported, the first three – dimensional, atomic-scale images of the binding site, where one of the drugs, epothilone A, interacts with an important protein controlling cell division.
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